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KMID : 0361420080320050501
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Journal of Korean Academy of Rehabilitation Medicine
2008 Volume.32 No. 5 p.501 ~ p.505
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Effect of Prefrontal Repetitive Transcranial Magnetic Stimulationon the Enhancement of Working Memory
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Ohn Suk-Hoon
Park Chang-Il
Lee Bo-Hyun
Kim Yun-Hee
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Abstract
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Objective: To investigate the effect of repetitive transcranial magnetic stimulation (rTMS) applied over the left prefrontal cortex on the enhancement of verbal working memory in healthy persons.
Method: High frequency (10 Hz) rTMS was applied over the left prefrontal cortex with the intensity of 100% resting motor threshold (RMT). A 3-back verbal working memory task was administered before, during (after applying 500 and 1,000 pulses, respectively), and 30 minutes after real or sham rTMS.
Results: Real rTMS, compared with sham stimulation, significantly improved working memory performance. Accuracy of response increased significantly after applying 1,000 pulses of real rTMS (p<0.05). This effect maintained for 30 minutes after completion of stimulation (p<0.05). The error rate and reaction time did not change with rTMS. There was no noticeable side effect during or after rTMS.
Conclusion: 1,000 pulses of 10 Hz rTMS administered to the left prefrontal cortex with the intensity of 100% RMT have positive impact on verbal working memory in healthy persons. Further study is necessary to address this effect of rTMS in patients with cognitive dysfunction.
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KEYWORD
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Repetitive transcranial magnetic stimulation, Working memory, Prefrontal cortex
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